Drug Development

M. tuberculosis Proteins May be Antibiotic Targets

Published in TB and Outbreaks Week, May 31st, 1999

Extracellular proteins of Mycobacterium tuberculosis may represent novel antibiotic targets, according to a report from the Los Angeles School of Medicine.

Mycobacterium tuberculosis and other pathogenic mycobacteria export abundant quantities of proteins into their extracellular milieu when growing either axenically or within phagosomes of host cells. One major extracellular protein, the enzyme glutamine synthetase, is of particular interest because of its link to pathogenicity.

"Pathogenic mycobacteria, but not nonpathogenic mycobacteria, export large amounts of this protein," G. Harth and M.A. Horwitz wrote ("An Inhibitor of...

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Source: TB and Outbreaks Week (1999-05-31)

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