"Induction of Langhans Type Multinucleated Giant Cells in vitro by Muramyl Dipeptide and the Supernatant of Concanavalin A-Stimulated Mononuclear Cells."

According to an abstract submitted by the authors to the 60th Annual Meeting of the Society for Investigative Dermatology, held May 5-9, 1999, in Chicago, Illinois, "Murarnyl dipeptide (MDP, N-acetylmuramyl-L-alanyl-D-isoglutarnine), a synthetic adjuvant, is a structural analogue of part of the bacterial peptidoglycan and produces massive epithelioid granulomas when injected into guinea pigs and rats. Anti-MIDP antibody showed positive staining of multinucleated giant cells (MGC) in sarcoidal lesions. In the present study, we examined the in vitro effect of MDP on the formation of MGC. The supernatant of concanavalin A-stimulated human peripheral blood mononuclear cells (conditioned...

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