Vaccine Development (TB)
"M. tuberculosis PHOP-Like Gene in Macrophages."
Published in TB and Outbreaks Week, June 14th, 1999
NIH Grant Number: 1R01AI40075-01A1. Grant Expires: March 31, 2002. Principle Investigator: Nancy A. Buchmeier. Performing Organization: University of California, Gilman and La Jolla Village Drive, San Diego, California 92093. Description: "The regulated expression of specific Mtb genes is likely required for the establishment of tuberculosis infections. One family of gene regulators present in M. tuberculosis is the two component regulators. Two-component regulatory systems sense and respond to environmental stimulation. TcrA (for two-component regulator) is a two-component regulatory gene found in Mtb. TcrA is present in M....
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