Pathology (Mycobacterium tuberculosis)
"Collagen Degrading Activity Associated with Mycobacterium species."
Published in TB and Outbreaks Week, June 28th, 1999
According to the authors' abstract of an article published in Thorax, "Background: The mechanism of Mycobacterium tuberculosis penetration into tissues is poorly understood but it is reasonable to assume that there is a contribution from proteases capable of disrupting the extracellular matrix of the pulmonary epithelium and the blood vessels. A study was undertaken to identify and characterise collagen degrading activity of M. tuberculosis. Methods: Culture filtrate protein extract (CFPE) was obtained from reference mycobacterial strains and mycobacteria isolated from patients with tuberculosis. The collagen-degrading activity of CFPE was determined...
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