Immunization
Rational Attenuation May be Key to Better TB Vaccines
Published in TB and Outbreaks Week, July 26th, 1999
Over the past few years much tuberculosis research has been aimed at the identification of individual mycobacterial antigens involved in the immune response to tuberculosis, with the aim of developing subunit vaccines. An alternative strategy to the development of novel vaccines consists of constructing mutant strains of mycobacteria that are rationally attenuated.
"The recent development of genetic tools for performing site-specific and random-site mutagenesis in organisms from the M. tuberculosis complex now renders...
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