Genomics

Sterol 14(alpha)-Demethylase of M. tb Characterized

Published in TB and Outbreaks Week, August 23rd, 1999

The catalytic properties of the sterol 14(alpha)-demethylase from Mycobacterium tuberculosis have been characterized by researchers at Nashville, Tennessee's Vanderbilt University.

Sterol 14(alpha)-demethylase encoded by CYP51 is a mixed-function oxidase involved in sterol synthesis in eukaryotic organisms. Completion of the Mycobacterium tuberculosis genome project revealed that a protein having homology to mammalian 14(alpha)-demethylases might be present in this bacterium.

Using genomic DNA from mycobacterial strain H(37)Rv, A. Bellamine and colleagues have established unambiguously that the CYP51-like gene encodes a bacterial...

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Source: TB and Outbreaks Week (1999-08-23)

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