Drug Resistance (TB)
katG Analysis Is Predictive of Isoniazid Resistance
Published in TB and Outbreaks Week, September 13th, 1999
The molecular prediction of isoniazid (INH) resistance in Mycobacterium tuberculosis is hampered by the need for specialized equipment, expertise, high costs, a limited range of detectable mutations, or several of these factors.
The rationale for the study, conducted by H. Rinder and colleagues from Germany's University of Munich, was to find a practical alternative to and to demonstrate generally valid problems with identifying INH resistance ("Culture-Independent Prediction of Isoniazid Resistance in Mycobacterium tuberculosis by katG Gene Analysis...
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