Published in TB and Outbreaks Week, September 13th, 1999
The molecular prediction of isoniazid (INH) resistance in Mycobacterium tuberculosis is hampered by the need for specialized equipment, expertise, high costs, a limited range of detectable mutations, or several of these factors.
The rationale for the study, conducted by H. Rinder and colleagues from Germany's University of Munich, was to find a practical alternative to and to demonstrate generally valid problems with identifying INH resistance ("Culture-Independent Prediction of Isoniazid Resistance in Mycobacterium tuberculosis by katG Gene Analysis...
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