Published in TB and Outbreaks Week, January 18th, 2000
New antibiotics to combat the emerging pandemic of drug-resistant strains of M. tuberculosis are urgently needed. In this study, G. Harth and colleagues investigated the effects on M. tuberculosis of phosphorothioate-modified antisense oligodeoxyribonucleotides (PS-ODNs) against the messenger RNA of glutamine synthetase, an enzyme whose export is associated with pathogenicity and with the formation of a poly-L-glutamate/glutamine cell wall structure.
"Treatment of virulent M. tuberculosis with 10 (mu)M antisense PS-ODNs...
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