Gene Expression
Type 2 Cytokines Linked to Immunity in TB
Published in TB and Outbreaks Week, January 25th, 2000
Researcher G.T. Seahand colleagues examined the extent of type 2 cytokine gene expression in patients with pulmonary tuberculosis (TB) using quantitative nested reverse-transcription polymerase chain reaction on freshly isolated peripheral blood mononuclear cells ("Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis," Journal of Infectious Diseases, January 2000;181(1):385-389).
Interleukin (IL)-4 and IL-13 mRNA expression was significantly greater in patients - median mRNA copy numbers were 1.7 and 1.1...
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