Leprosy

TB Database Used for Mycobacterium leprae Gene Search

Published in TB and Outbreaks Week, February 1st, 2000

Extensive sequence homology between Mycobacterium leprae LSR antigen and its M. tuberculosis counterpart was studied by researchers in Norway.

The M. leprae LSR (12 kDa) protein antigen has been reported to mimic whole cell M. leprae in T-cell responses across the leprosy spectrum. In addition, B-cell responses to specific sequences within the LSR antigen have been shown to be associated with immunopathological responses in leprosy patients with erythema nodosum leprosum.

In this study, F. Oftung and colleagues from Norway's National Institute of Public Health applied the M. leprae LSR DNA sequence as query to...

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Source: TB and Outbreaks Week (2000-02-01)

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