Tuberculosis

Genes Encoding Mycolyl Transferase Studied

Published in TB and Outbreaks Week, February 15th, 2000

Targeted disruption of two genes encoding mycolyl transferase and fibronectin-binding activities in Mycobacterium tuberculosis is critical to determining the pathogenesis of tuberculosis.

The mechanism of pathogenesis of M. tuberculosis is thought to be multifactorial. Among the putative virulence factors is the antigen 85 (Ag85) complex.

"This family of exported fibronectin-binding proteins consists of members Ag85A, Ag85B, and Ag85C and is most prominently represented by 85A and 85B," L.Y. Armitige and colleagues from The University of Texas at Houston wrote ("Disruption of the Genes Encoding Antigen 85A and Antigen 85B of...

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Source: TB and Outbreaks Week (2000-02-15)

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