Tuberculosis Vaccines

Dendritic Cells Important in Anti-Mycobacterial T-Cell Responses

Published in TB and Outbreaks Week, March 14th, 2000

Researchers from London, England, reported dendritic cells (DCs) were important in priming anti-mycobacterial T-cell responses.

Ricardo E. Tascon and associates from the National Institute for Medical Research conducted a study to help clarify the cellular basis for the induction of protective anti-mycobacterial CD4⁺ and CD8⁺ T-cell responses. Researchers explained that DCs are readily infected with Mycobacterium tuberculosis (Mtb) and are present in the airway epithelium and lung parenchyma.

"Immortalized DC lines are a good model to study the molecular mechanisms involved in the activation and presentation of bacterial...

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Source: TB and Outbreaks Week (2000-03-14)

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