Tuberculosis
Rifampicin Does Not Activate the Glucocorticoid Receptor
Published in TB and Outbreaks Week, May 23rd, 2000
To determine whether rifampicin displayed glucocorticoid-like effects in human neuroblastoma SK-N-MC cells or mouse hippocampal HT22 cells, A.S. Herr and colleagues from the Max Planck Institute of Psychiatry, Germany, conducted a study using reporter gene assays.
Herr et al. found that the antibiotic did not elicit transactivation of GR in either cell types; however, a potent transcriptional response was caused by cortisol or dexamethasone. The same HepG2 cell line that was originally used to demonstrate...
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