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Nosocomial Infection

Lethal Antibiotic Created to Cause Resistant Bacteria to Self-Destruct

Published in TB and Outbreaks Week, August 1st, 2000

NewBiotics Inc., San Diego, California, reported laboratory tests of its NB2001 drug candidate show the company's drug design causes resistant bacteria associated with hospital-acquired infections to self-destruct.

The findings were reported at the American Society of Microbiology International Conference on Emerging Infectious Diseases, held in Atlanta, Georgia, July 16-19, 2000.

"Penicillin-resistant organisms often produce beta-lactamase, an enzyme that blocks the effectiveness of penicillin and cephalosporin antibiotics," explained H. Michael Shepard, PhD, NewBiotics. "NB2001 releases a highly potent bacterial toxin that is triggered by this...

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