Rickettsia

Assays Used in Combination Best for Differentiating Murine and Epidemic Typhus

Published in TB and Outbreaks Week, September 5th, 2000

Findings from research conducted in France at the University Mediterranee show that by using indirect fluorescent antibody assay (IFA) in combination with Western blotting techniques, typhus caused by Rickettsia typhi or R. prowazekii can be better differentiated.

"Differentiation of murine typhus due to Rickettsia typhi and epidemic typhus due to R prowazekii is critical epidemiologically but difficult serologically," B. Lascola and co-authors stated ("Serological differentiation of murine typhus and epidemic typhus using cross-adsorption and Western blotting," Clinical and Diagnostic Laboratory Immunology, 2000;7(4):612-616).

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Source: TB and Outbreaks Week (2000-09-05)

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