Malaria

Endogenous Gamma Interferon is Protective Against Blood-Stage Plasmodium chabaudi

Published in TB and Outbreaks Week, September 19th, 2000

Endogenous gamma interferon (IFN-gamma) is necessary for the development of host protective immunity against blood-stage Plasmodium chabaudi malaria, researchers in Canada report.

"The role of endogenous IFN-gamma in protective immunity against blood-stage P. chabaudi AS malaria was studied using IFN-gamma gene knockout (GKO) and wild-type (WT) C57BL/6 mice," wrote Z. Su and colleagues, Montreal General Hospital. "Following infection with 10⁶ parasitized erythrocytes, GKO mice developed significantly higher parasitemia during acute infection than WT mice and had severe mortality."

In infected GKO mice, the production of...

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Source: TB and Outbreaks Week (2000-09-19)

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