Published in TB and Outbreaks Week, September 19th, 2000
"The role of endogenous IFN-gamma in protective immunity against blood-stage P. chabaudi AS malaria was studied using IFN-gamma gene knockout (GKO) and wild-type (WT) C57BL/6 mice," wrote Z. Su and colleagues, Montreal General Hospital. "Following infection with 106 parasitized erythrocytes, GKO mice developed significantly higher parasitemia during acute infection than WT mice and had severe mortality."
In infected GKO mice, the production of...
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