Bacteriology
Gallium Marks Iron Factors in Macrophages that Host Mycobacteria
Published in TB and Outbreaks Week, November 21st, 2000
Although studies have shown that Mycobacterium tuberculosis and M. avium complex (MAC) both need iron to grow, the ability to study how that iron is acquired and metabolized in phagocytic cells has been limited up until now.
"Based on the ability of gallium Ga3+ to concentrate within mononuclear phagocytes and on evidence that Ga disrupts cellular Fe (iron)-dependent metabolic pathways by substituting for Fe3+ and failing to undergo redox cycling, we hypothesized that Ga could disrupt Fe...
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