Tuberculosis

Auxotrophic Mutants Evaluated as Vaccine Candidates

Published in TB and Outbreaks Week, February 13th, 2001

- by Michelle Marble, staff medical writer -- Researchers in England report that disruption of genes responsible for virulence of Mycobacterium tuberculosis may result in mutants useful as vaccine candidates.

"Auxotrophic mutants of M. tuberculosis have been proposed as new vaccine candidates," wrote Debbie A. Smith and colleagues from the London School of Hygiene and Tropical Medicine. "We have analyzed the virulence and vaccine potential of M. tuberculosis strains containing defined mutations in genes involved in methionine (metB), proline (proC), or tryptophan (trpD) amino acid biosynthesis."

Smith et al....

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Source: TB and Outbreaks Week (2001-02-13)

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