Tuberculosis

T-Cell Expression Cloning Used to Create Novel Vaccine

Published in TB and Outbreaks Week, February 13th, 2001

- by Michelle Marble, staff medical writer -- According to a study from the United States, advances in technology are facilitating the development of novel and effective vaccines against Mycobacterium tuberculosis.

"Infection of C57BL/6 mice with Mycobacterium tuberculosis results in the development of a progressive disease during the first two weeks after challenge," stated Y.A.W. Skeiky and colleagues, Infectious Diseases Research Institute, Seattle, Washington. "Thereafter, the disease is controlled by the emergence of protective T cells. We have used this infection model in conjunction with direct T-cell expression cloning to identify antigens (Ags)...

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Source: TB and Outbreaks Week (2001-02-13)

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