Japanese Encephalitis
Chimera Vaccine Evaluated
Published in TB and Outbreaks Week, February 20th, 2001
"A yellow fever virus (YFV)/Japanese encephalitis virus (JEV) chimera in which the structural proteins prM and E of YFV 17D are replaced with those of the JEV SA14-14-2 vaccine strain is under evaluation as a candidate vaccine against Japanese encephalitis," wrotes J. Arroyo and colleagues, St. Louis University, Missouri. "The chimera (YFV/JEV SA14-14-2, or ChimeriVax-JE) is less neurovirulent than is YFV 17D vaccine in mouse and nonhuman primate models."
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