Coinfection (HIV/TB)

Mechanism Uncovered For Drug-Drug Interaction With Isoniazid

Published in TB and Outbreaks Week, March 20th, 2001

by N.R. Saltmarsh, staff medical writer -- HIV drugs that are metabolized by two specific enzymes are more likely to interact with the tuberculosis drug isoniazid, with potentially toxic results.

Although researchers had already observed that isoniazid could increase concentrations of other drugs in the bloodstream, they had not established a mechanism for this effect.

Predicting the likelihood of this interaction has become more important as TB patients have become sicker, said Z. Desta and colleagues working at Georgetown University.

"The use of isoniazid has increased over the past years, largely as a result of the co-epidemic...

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Source: TB and Outbreaks Week (2001-03-20)

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