Tuberculosis

Additional Rifampin-Resistant Strains Identified

Published in TB and Outbreaks Week, March 20th, 2001

by N.R. Saltmarsh, staff medical writer -- Researchers in Germany have identified additional strains of tuberculosis resistant to rifampin and say a test to identify these resistant strains should be part of screening prior to treatment.

V176F is a mutation located on the rpoB gene that is associated with rifampin resistance. M. Heep and colleagues reported in the Journal of Clinical Microbiology on the prevalence of V176F in 80 strains of rifampin-resistant Mycobacterium tuberculosis isolated in 1997.

The researchers detected one instance of V176F mutation among the 80 slides, and five additional instances in 18 rifampin-resistant...

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Source: TB and Outbreaks Week (2001-03-20)

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