Published in TB and Outbreaks Week, March 20th, 2001
This ability to change conformation allows the hybrid prion to bridge a species barrier and "infect" proteins from two distantly related species of yeast. This phenomenon, say the scientists, may be a key to understanding how prions derived from cows infected with bovine spongiform encephalopathy (BSE), or "mad cow disease," can hop the species barrier and infect humans.
The ability of a single prion protein to fold into multiple infectious forms means that knowledge of...
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