Ebola Virus

Cytotoxic T Lymphocyte-Based Vaccine Prevents Infection In Mice

Published in TB and Outbreaks Week, March 27th, 2001

by N.R. Saltmarsh, staff medical writer - Researchers have demonstrated that mice vaccinated with Ebola virus nucleoprotein are completely protected from a lethal challenge of the viral hemorrhagic fever.

"Cytotoxic T lymphocytes (CTLs) are proposed to be critical for protection from intracellular pathogens such as Ebola virus. However, there have been no demonstrations that protection against Ebola virus is mediated by Ebola-virus-specific CTLs," noted Julie A. Wilson and colleagues at the U.S. Army Medical Research Institute of Infectious Diseases

Wilson et al. vaccinated mice with Venezuelan equine encephalitis virus replicons encoding the Ebola...

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Source: TB and Outbreaks Week (2001-03-27)

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