Prion Disease

Cobra Venom Factor Delays Onset Of Scrapie

Published in TB and Outbreaks Week, April 10th, 2001

Studies of scrapie, a sheep disease classified as a transmissible spongiform encephalopathy (TSE), may offer clues to the route of infection of bovine spongiform encephalopathy (BSE) and new-variant Creutzfeldt-Jakob disease (vCJD).

One agent possibly responsible for scrapie and other TSEs is a prion, an exclusively host-coded protein that is modified to a protease-resistant form after infection.

The present consensus is that the most likely route of infection of BSE and vCJD has been through the food chain - eating products contaminated with abnormal prion protein. The infectious prion then replicates in lymph tissues before moving through the...

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Source: TB and Outbreaks Week (2001-04-10)

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