Lyme Disease

Decorin May Be Key Player In Pathogenesis

Published in TB and Outbreaks Week, May 8th, 2001

by N.R. Saltmarsh, staff medical writer - Mice deficient in decorin appear better able to resist infection with Borrelia burgdorferi, the causative agent of Lyme disease, according to a report in the Journal of Clinical Investigation.

B. burgdorferi expresses two surface-exposed decorin-binding adhesins, DbpA and DbpB. Noting that microbial adhesion to the host tissue is an early, critical step in Lyme disease pathogenesis, E.L. Brown and colleagues working in the United States bred a decorin-deficient (Dcn^-/-) mouse to observe the effect of B. burgdorferi infection.

They infected the Dcn^-/- mice...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of TB and Outbreaks Week

Source: TB and Outbreaks Week (2001-05-08)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry