Published in TB and Outbreaks Week, May 8th, 2001
B. burgdorferi expresses two surface-exposed decorin-binding adhesins, DbpA and DbpB. Noting that microbial adhesion to the host tissue is an early, critical step in Lyme disease pathogenesis, E.L. Brown and colleagues working in the United States bred a decorin-deficient (Dcn-/-) mouse to observe the effect of B. burgdorferi infection.
They infected the Dcn-/- mice...
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