Leishmaniasis

Tumor Necrosis Factor Essential For Control Of Infection

Published in TB and Outbreaks Week, May 15th, 2001

by N.R. Saltmarsh, staff medical writer - Mice that are normally resistant to the protozoan parasite Leishmania major quickly succumb to fatal infection in the absence of tumor necrosis factor (TNF), say researchers working in Germany.

P. Wilhelm and colleagues demonstrated that TNF is critical for control of leishmaniasis by removing the TNF gene in mice infected with L. major. Their results were published in the Journal of Immunology

Their research contradicts previous studies with mice deficient for both TNF receptors, which suggested that TNF plays only a limited role in the control of parasite replication in vivo.

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Source: TB and Outbreaks Week (2001-05-15)

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