Published in TB and Outbreaks Week, May 15th, 2001
P. Wilhelm and colleagues demonstrated that TNF is critical for control of leishmaniasis by removing the TNF gene in mice infected with L. major. Their results were published in the Journal of Immunology
Their research contradicts previous studies with mice deficient for both TNF receptors, which suggested that TNF plays only a limited role in the control of parasite replication in vivo.
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