Malaria

DNA Vaccine Is Immunogenic But Falls Short of Full Protection

Published in TB and Outbreaks Week, June 19th, 2001

by N.R. Saltmarsh, staff medical writer - A DNA vaccine consisting of Plasmodium yoelii heat shock protein 60 (PyHsp60) offers enough protection against the sporozoite in mice to warrant further investigation, but cannot currently be considered reliable, say researchers at the U.S. Naval Medical Research Center, Johns Hopkins University, and the University of Maryland.

G.I. Sanchez and associates cloned PyHsp60 into VR1012 and VR1020 mammalian expression vectors. They vaccinated mice intramuscularly at zero, three and nine weeks with 100 (mu)g of PyHsp60 alone or combined with 30 (mu)g of pmur granulocyte-macrophage colony-stimulating factor (GM-CSF).

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Source: TB and Outbreaks Week (2001-06-19)

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