Leishmaniasis

Vaccine Protects Seven of Eight Monkeys From Fatal L. Donovani

Published in TB and Outbreaks Week, August 14th, 2001

by N.R. Saltmarsh, staff medical writer - Autoclaved Leishmania major (ALM) along with BCG, shows promise for protection against cutaneous leishmaniasis and should be evaluated in humans, say researchers in India, working in cooperation with the World Health Organization (WHO).

A. Misra and associates vaccinated eight monkeys with 1 mg each of ALM plus bacillus Calmette-Guerin (BCG), then challenged them intravenously 60 days later with 100 x 10⁶ amastigotes. They then assessed parasite load in splenic tissue on days 45, 90 and 180.

Seven of the eight vaccinated monkeys developed infection but recovered by day 180, but the eighth...

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Source: TB and Outbreaks Week (2001-08-14)

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