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Tuberculosis

Study Supports Tuberculin Skin Test As Indicator Of Immunity In BCG-Vaccinated Subjects

Published in TB and Outbreaks Week, August 21st, 2001

Whether or not the tuberculin skin test reflects immunity against tuberculosis in people vaccinated with bacillus Calmette-Guerin is a matter of ongoing debate.

Researchers at Sahlgrenska University Hospital, Goteborg, Sweden, tried to shed some light on the controversy. They reported their findings in the August 2001 European Respiratory Journal.

Swedish health care workers (n=381) were tuberculin skin-tested. From these, 11 subjects with negative tuberculin reactions (<6 mm) were matched for age and sex with 11 subjects with large positive reactions (>15 mm). Lymphocyte proliferation and production of interferon-gamma were analyzed...

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