Mycobacteria

T-Cell Surface Membranes Involved In Immune Response To Tuberculosis

Published in TB and Outbreaks Week, November 6th, 2001

by Michael Greer, senior medical writer - The immune response to tuberculosis infection is partly mediated by T-cell surface membrane stimulation, researchers in England report.

"Mycobacterium tuberculosis alone induces small, donor-variable amounts of tumor necrosis factor (alpha) (TNF-(alpha)) from primary human monocytes in vitro," explained Jan Warwick-Davies and colleagues at St. George's Hospital Medical School in London.

The addition of activated T-cells or their isolated membranes to such cultures triggered a huge increase in cytokine output, according to Warwick-Davies and coauthors.

Fixed, activated T cells (FAT) induced...

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Source: TB and Outbreaks Week (2001-11-06)

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