Malaria

Multidrug Resistance Gene May Not Affect Mefloquine Susceptibility

Published in TB and Outbreaks Week, January 29th, 2002

by Michael Greer, senior medical writer - Contrary to conventional wisdom, researchers in Europe and Africa report that mutations in a malaria gene linked to multidrug resistance may not affect the parasite's susceptibility to mefloquine.

"The identification of parasite molecular markers involved in resistance to antimalarial compounds is of great interest for monitoring the development and spread of resistance in the field," according to Denise P. Mawili-Mboumba and colleagues at Albert Schweitzer Hospital in Lambarene, Gabon, and the University of Tubingen in Tubingen, Germany. "Polymorphisms in Plasmodium falciparum multidrug resistance gene 1 (pfmdr1)...

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Source: TB and Outbreaks Week (2002-01-29)

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