Legionellosis

Protein Plays Key Role In Bacteria's Virulence

Published in TB and Outbreaks Week, February 12th, 2002

A key protein discovered in the bacterium that causes Legionnaires disease may help explain how these common aquatic organisms became virulent human pathogens.

When the Legionella bacterium invades a host, it begins its replication process by setting up a protected cavity (vacuole) for itself within the host's cells. The bacteria use a protein-secreting apparatus to subvert normal cellular membrane traffic and set up this specialized home base, but the specific proteins involved have remained elusive.

Now, Hiroki Nagai and colleagues at Yale University, Emory University, and the National Institute of Genetics (Shizuoka, Japan) show that the...

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Source: TB and Outbreaks Week (2002-02-12)

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