Tuberculosis

Work Points To Possible New Target For TB Drugs

Published in TB and Outbreaks Week, February 19th, 2002

Scientists at Weill Cornell Medical College, led by Dr. Carl Nathan, have found that M. tuberculosis defends itself against oxidative stress by using a "bucket brigade" of proteins including two proteins that have been widely known as being involved in essential metabolism.

One of the challenges posed by the tubercle bacillus is to understand how the bacillus, once it infects tissue, persists for a person's entire lifetime despite the attack of the body's immune system. Mycobacterium tuberculosis persists despite prolonged oxidative and nitrosative stress - forces that the immune system uses to kill many other invading pathogens.

"This...

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Source: TB and Outbreaks Week (2002-02-19)

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