Cell Biology

Researchers identify mechanisms by which drug combinations kill fungal infections

Published in TB and Outbreaks Week, April 16th, 2002

Molecular biologists in the mycology research unit at Duke University Medical Center have traced cellular pathways that are targeted to enhance the action of drugs used to treat fungal infections in people with compromised immune systems, such as those undergoing organ and bone marrow transplants.

The discovery of how the immune-suppressing drugs enhance the action of antifungal drugs could lead to the development of new drugs designed to treat fungal infections such as systemic yeast infections and often-deadly cryptococcal infections.

Led by Dr. Joseph Heitman, who is a Howard Hughes Medical Institute investigator at Duke, the research team...

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Source: TB and Outbreaks Week (2002-04-16)

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