Malaria

Interleukin-18 plays key role in host defense

Published in TB and Outbreaks Week, June 18th, 2002

by Michael Greer, senior medical writer - Researchers in India and Japan have identified a cytokine playing a key role in the body's immune response to malaria.

Ram Pyare Singh and colleagues at the International Center for Genetic Engineering and Biotechnology and Safdarjung Hospital in New Delhi, and Hyogo College of Medicine in Nishinomiya evaluated interleukin (IL)-18 activity after infection with Plasmodium parasites

IL-18 augments the production of other inflammatory cytokines to help stave off blood-stage malaria infection, Singh and coauthors found.

The researchers used a murine model to assess the role of IL-18 and...

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Source: TB and Outbreaks Week (2002-06-18)

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