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Tuberculosis Therapy

Thalidomide analog adjunct effective against tuberculous meningitis

Published in TB and Outbreaks Week, July 30th, 2002

by Michael Greer, senior medical writer - Researchers in the United States say that a novel immunomodulatory agent may help prevent long-term sequelae from tuberculosis-related meningitis.

"Tuberculous meningitis (TBM), the most severe form of Mycobacterium tuberculosis infection in humans, is associated with significant morbidity and mortality despite successful treatment with antituberculous drugs," explained Liana Tsenova and colleagues working at The Rockefeller University in New York City and Celgene Corporation in Warren, New Jersey. "This is due to the irreversible brain damage subsequent to the local inflammatory response of the host to M....

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