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Infectious Disease Therapy

Superantigens can enhance antimicrobial, anti-HIV immune activity

Published in TB and Outbreaks Week, November 26th, 2002

by Michael Greer, senior medical writer - Researchers in the United States have identified a novel means to improve immune responses to HIV and other pathogens.

"Superantigens are microbial proteins that induce massive activation, proliferation, and cytokine production by CD4+ T cells via specific Vbeta elements on the TCR [T cell receptor]," explained Barbara A. Torres and colleagues working at the University of Florida in Gainesville.

These proteins can be used to augment CD4 cell-induced humoral activity against a number of microbial and viral antigens, Torres and coauthors found.

The researchers evaluated the effect of...

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