Infectious Disease Therapy
Amikacin enhances rifampin activity against Mycobacterium ulcerans
Published in TB and Outbreaks Week, December 3rd, 2002
Herve Dega and colleagues at the Pitie-Salpetriere Faculty of Medicine in Paris examined amikacin's activity against Mycobacterium ulcerans, the pathogen that causes Buruli ulcer, when administered with rifampicin.
The combination of amikacin and rifampicin (RIF) was significantly more effective than other rifampicin-based regimens in animals, Dega and coauthors found.
The researchers evaluated several antimicrobial regimens in a murine model of Buruli...
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