Sepsis

Anti-inflammatory agents work best in patients at greatest risk of death

Published in TB and Outbreaks Week, January 14th, 2003

The efficacy of treatment with anti-inflammatory agents for sepsis depends on the severity of the underlying disease as manifested by risk of death, according to a new analysis.

Peter Q. Eichacker, MD, of the critical care department, National Institutes of Health, Bethesda, Maryland, along with 9 associates, performed a retrospective analysis of 22 human clinical studies and 38 preclinical animal trials, along with a prospective large confirmatory animal investigation.

The investigators were testing their hypothesis that anti-inflammatory agents were efficacious in septic patients who had a higher risk of death and harmful in those with low risk. ...

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Source: TB and Outbreaks Week (2003-01-14)

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