Malaria Therapy
Amino acid 23 mediates cysteine protease activity in murine P. falciparum
Published in TB and Outbreaks Week, January 28th, 2003
"Cysteine proteases of Plasmodium falciparum, known as falcipains, have been identified as hemoglobinases and potential drug targets. As anti-malarial drug discovery requires the analysis of non-primate malaria, genes encoding related cysteine proteases of the rodent malaria parasites P. vinckei (vinckepain-2) and P. berghei (berghepain-2) were characterized," researchers in the United States report.
"These genes encoded fairly typical papain-family proteases, but they contained an unusual substitution of Gly(23) with Ala (papain numbering system). Vinckepain-2 was expressed in Escherichia coli, solubilized, refolded and autoprocessed to an...
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