Human Papillomavirus

Transactivation by E6 could contribute to oncogenesis

Published in TB and Outbreaks Week, February 4th, 2003

According to recent research from the United States, "The expression of human papillomavirus (HPV) E6 oncoprotein is causally linked to high-risk HPV-associated human cancers. We have recently isolated hADA3, the human homologue of yeast transcriptional co-activator yADA3, as a novel E6 target.

"Human ADA3 binds to the high-risk (cancer-associated) but not the low-risk HPV E6 proteins and to immortalization-competent but not to immortalization-defective HPV16 E6 mutants, suggesting a role for the perturbation of hADA3 function in E6-mediated oncogenesis.

"We demonstrate here that hADA3 directly binds to the retinoic X receptor (RXR)alpha in vitro...

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Source: TB and Outbreaks Week (2003-02-04)

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