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Natural Antibacterials

Many cationic polypeptides in human airway fluid are found to be active

Published in TB and Outbreaks Week, February 18th, 2003

"In a search for direct evidence leading to the biological relevance of airway secretions in innate host defense, we characterized the antibacterial function of cationic polypeptides within minimally manipulated nasal fluid. In this study, we show that cationic antimicrobial polypeptides are responsible for most of the bactericidal activity of whole nasal fluid. The removal of cationic polypeptides using a cation exchange resin ablated the activity of nasal fluid against Escherichia coli, Listeria monocytogenes, and Pseudomonas aeruginosa," researchers in the United States report.

"By using a novel proteomic approach, we identified a dozen cationic...

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