Infectious Disease
Survival and growth of Francisella tularensis in Acanthamoeba castellanii
Published in TB and Outbreaks Week, March 4th, 2003
F. tularensis "is a highly infectious, facultative intracellular bacterium which causes epidemics of tularemia in both humans and mammals at regular intervals," explained H. Abd and colleagues at the Swedish Defense Research Agency. "The natural reservoir of the bacterium is largely unknown, although it has been speculated that protozoa may harbor it."
"To test this hypothesis, Acanthamoeba castellanii was cocultured with a strain of F. tularensis engineered to produce green fluorescent protein (GFP) in a nutrient-rich...
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