Toxoplasmosis

DNA vaccine primes CD8+ T cells to control Toxoplasma gondii infection

Published in TB and Outbreaks Week, March 4th, 2003

According to recent research from Belgium, "Protective immunity against Toxoplasma gondii is known to be mediated mainly by T lymphocytes and gamma interferon (IFN-gamma). The contribution of CD4+ and CD8+ T-lymphocyte subsets to protective immune responses against T. gondii infection, triggered by a GRA1 (p24) DNA vaccine, was assessed in this study."

"In vitro T-cell depletion experiments indicated that both CD4+ and CD8+ T-cell subsets produced IFN-gamma upon restimulation with a T. gondii lysate," reported T. Scorza and collaborators at the Pasteur Institute of Brussels. "In addition, the GRA1 DNA vaccine elicited CD8+ T cells that were shown...

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Source: TB and Outbreaks Week (2003-03-04)

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