Tuberculosis Pathogenesis
Monocyte infection induces unique TNF-alpha enhanceosome
Published in TB and Outbreaks Week, March 4th, 2003
TNF-alpha "plays an important role in host containment of infection by Mycobacterium tuberculosis, one of the leading causes of death by an infectious agent globally," explained R. Barthel and coauthors.
"Using the pathogenic M. tuberculosis strain H37Rv," Barthel and coworkers found that "upon stimulation of monocytic cells by M. tuberculosis a unique TNF-alpha enhanceosome is formed, and it is distinct from the TNF-alpha enhanceosome that forms in T cells stimulated by antigen engagement or virus...
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