Infectious Disease

Murine coccidioidal meningitis model enables detailed study

Published in TB and Outbreaks Week, March 25th, 2003

A novel animal model may facilitate research on coccidioidal meningitis.

This infection "is lethal in humans," according to a recent study from California.

"A reproducible murine model was established by lumbar intrathecal injection of Coccidioides immitis arthroconidia," explained P. Kamberi and colleagues at the Santa Clara Valley Medical Center.

After infection, "cerebrospinal fluid (CSF) samples were obtained by cisternal puncture" for examination, they said. "Lethal infection developed in all mice given 10-60 colony-forming units (cfu)."

"Lethargy, ataxia, or paralysis preceded death. Temporal...

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Source: TB and Outbreaks Week (2003-03-25)

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