Meningitis

Rifampin pretreatment reduces ceftriaxone-induced neuronal damage

Published in TB and Outbreaks Week, April 15th, 2003

by Michael Greer, senior medical writer - Rifampin (RIF) ameliorates the neurotoxic effects of ceftriaxone in bacterial meningitis patients, researchers in Germany report.

RIF "releases smaller quantities of lipoteichoic acids (LTAs) from Streptococcus pneumoniae than ceftriaxone (CRO)," explained Joachim Gerber and colleagues at Georg-August University in Gottingen. "Due to the rapid development of resistance, RIF cannot be used as a single agent for therapy of bacterial meningitis."

However, RIF pretreatment reduced the amount of streptococcal LTAs released during CRO therapy, Gerber and coauthors found.

The researchers...

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Source: TB and Outbreaks Week (2003-04-15)

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