Published in TB and Outbreaks Week, April 22nd, 2003
Dolores Lopez-Maderuelo and colleagues at Hospital La Paz and Universidad Autonoma de Madrid examined the effect of interferon (IFN)-gamma and interleukin (IL)-10 gene polymorphisms on "cytokine production by peripheral blood mononuclear cells and tuberculosis susceptibility."
A mutation that resulted in low IFN-gamma production almost quadrupled the risk of tuberculosis development, Lopez-Maderuelo and coauthors found.
The researchers investigated the effects of the IFN-gamma gene +874 T/A...
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