Tuberculosis Pathogenesis

Interferon gamma and interleukin-10 mutations heighten susceptibility

Published in TB and Outbreaks Week, April 22nd, 2003

by Michael Greer, senior medical writer - Cytokine gene mutations can increase their carriers' tuberculosis risk, researchers in Spain warn.

Dolores Lopez-Maderuelo and colleagues at Hospital La Paz and Universidad Autonoma de Madrid examined the effect of interferon (IFN)-gamma and interleukin (IL)-10 gene polymorphisms on "cytokine production by peripheral blood mononuclear cells and tuberculosis susceptibility."

A mutation that resulted in low IFN-gamma production almost quadrupled the risk of tuberculosis development, Lopez-Maderuelo and coauthors found.

The researchers investigated the effects of the IFN-gamma gene +874 T/A...

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Source: TB and Outbreaks Week (2003-04-22)

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