Infectious Disease
Novel assay enables quantification of ofloxacin isomers
Published in TB and Outbreaks Week, April 29th, 2003
"Ofloxacin, a chiral fluoroquinolone, possesses two optical isomers. The antibacterial activity of S-(-)-ofloxacin is reported to be 8-128 times higher than that of R-(+)-ofloxacin," researchers in Germany explained.
B. Awadallah and colleagues at the University of Tuebingen developed a capillary zone electrophoresis-based assay "to quantify the enantiomers of ofloxacin in highly diluted samples (20-700 ng/mL for each enantiomer)."
"After fluid-fluid extraction of ofloxacin from physiological solution, electrokinetic injection was employed to improve the...
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